BIE 3400 - Kinetics and Bioreactor Design

3 lecture hours 0 lab hours 3 credits

Course Description
This course is an introduction to the reaction engineering. It addresses the selection of the optimal configuration and size of production scale bio and chemical reactors for specific process applications. Course topics include reaction kinetics and fundamental reaction parameters, the design of different reactor types (batch, semi-batch, continuous flow reactors (CSTR, Chemostats, PFR, PBR) Chemostats), substrate consumption kinetics, enzyme kinetics for bioreactions, mole/mass and energy balances on the bio and/or chemical reactors. The design of fermentation reactors and cell culture type bioreactors and their applications are discussed. (prereq: BIE 3420, BIE 3520, and CHM 2310) (quarter system prereq: BI 102, CH 223, EB 3510, and EB 3620)

Course Learning Outcomes
Upon successful completion of this course, the student will be able to:

Describe the fundamental principles of reaction kinetics and reactor design and apply them in chemical and bio engineering
Distinguish between various types and arrangements of reactors and describe their operations with or without heat exchange in chemical and bio industry
Perform macroscopic mole/mass and energy balances required to design batch and flow reactors
Interpret and analyze lab data to ascertain the kinetics of a reaction.
Identify problems in chemical and bio reactor design, formulate the alternative solutions and use a mathematical tool to solve systems of equations

Prerequisites by Topic

Basic principles of chemical and biochemical reaction kinetics
Mass and energy balances
Knowledge of transport phenomena and thermodynamics
Basic level of computer programming

Course Topics

Mole balances-design equations
Types of reactors, configurations of bioreactors
Conversion and reactor sizing
Reactor arrangement/staging, rate laws, and stoichiometry
Numerical solutions
Isothermal reactor design
Pressure drop in reactors
Design of batch, fed-batch, PFR, PBR, CTSR, membrane, recycle and aerated reactors
Analysis of rate data, determination of reaction kinetics
Multiple reactions
Non elementary reactions and PSSH
Bioreactions, enzymatic reactions, inhibition of enzyme reactions
Cell growth kinetics/rate laws
Bioreactors, design, scale up, and operation
Introduction to mixing and mass transfer in bioreactors
Nonisothermal reactor design
Heat effects/energy balance
Demonstration of polymath
SAChE Certification ELA-962: Chemical Reactivity Hazards

Coordinator
Dr. Serdar Ozturk

Announcement

The Raider Return

Milwaukee School of Engineering

Connect With MSOE

BIE 3400 - Kinetics and Bioreactor Design