BIE 4200 - Engineering Controlled Drug Delivery and Nanomedicine

2 lecture hours 2 lab hours 3 credits

Course Description
This course addresses the engineering principles behind the development and understanding of controlled drug delivery systems and nanomedicine. This course focuses on understanding the drug delivery process and industrial-relevant techniques including nanotechnology used for the design of specific formulations. The topics range from general biological barriers to drug delivery and pharmacokinetics, synthetic drug/gene delivery vectors, targeted drug delivery to medical nanotechnology and nanomedicine. (prereq: BIE 3200) (quarter system prereq: EB 2250)

Course Learning Outcomes
Upon successful completion of this course, the student will be able to:

Discuss basic pharmacology, pharmacokinetics, and pharmacodynamics
Discuss the principles of prodrug design and design prodrugs as drug delivery systems
Discuss physiological and chemical barriers for drug delivery
Compare and design the carriers for drug delivery
Assess the emerging biomedical nanotechnology
Discuss molecular nanotechnology applications in pharmaceuticals and medicine
Discuss targeted drug delivery, especially to the brain and tumor
Design targeted drug delivery systems
Compare and select different controlled drug delivery systems and understand the FDA requirements for controlled release systems
Design controlled drug delivery systems under the FDA requirements

Prerequisites by Topic

Biopolymers, nanomaterials, and nanostructures
Biocompatibility and biocompatibility
Bionanotechnology and nanobiotechnology

Course Topics

Introduction to drug delivery
Pharmacology, pharmacokinetics, and pharmacodynamics
Physiological and biochemical barriers to drug delivery
Prodrugs as drug delivery
Engineered carriers and vectors in drug delivery
Diffusion-controlled drug delivery systems
Dissolution-controlled drug delivery systems
Erodible drug delivery systems
Osmotic-controlled drug delivery systems
Oral controlled-release delivery
The nature of nanotechnology (from nanoscience to nanotechnology)
Medical nanotechnology and nanomedicine
Special topic: design of nanoparticles for cancer treatment
Targeting approaches to drug delivery
Site-specific drug delivery
Market and FDA requirements for controlled release products

Laboratory Topics

Biopolymer purification to achieve the pharmaceutical grade
Drug stability
Alginate-based microcapsules preparation
Polymeric nanofiber preparation
Liposome preparation
Release profiles of encapsulated drugs
Biosynthesis of nanoparticles for pharmaceutical and biomedical application

Coordinator
Dr. Wujie Zhang

Announcement

The Raider Return

Milwaukee School of Engineering

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BIE 4200 - Engineering Controlled Drug Delivery and Nanomedicine