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Apr 19, 2024
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EB 3860 - Prokaryotic Processes3 lecture hours 0 lab hours 3 credits
Course Description
This course explores how to harness the metabolic diversity of prokaryotes for biocatalysis and bioremediation applications. The energetics and regulation of diverse metabolic strategies are discussed in the context of environmental and industrial case studies. Signal transduction and quorum sensing are examined as tools for managing natural and engineered microbial populations. Students will apply these concepts to solve problems in biocatalytic pathway prediction and control. (prereq: EB 2410 and EB 2240 )
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
- Express familiarity with prokaryotic metabolic diversity
- Describe the influence of various environmental factors on prokaryotic metabolism
- Evaluate microbial communities as engineered systems and make informed choices about microbial system design
- Make reasonable hypotheses about metabolic pathways for novel substrates/products
- Describe mechanisms of global regulation, signal transduction, and quorum sensing in bacteria
- Discuss current and future applications of prokaryotic control strategies to a variety of engineering challenges
Prerequisites by Topic
- Fundamentals of cellular metabolism and bioenergetics
- Gene regulation and prokaryotic operons
Course Topics
- Introduction to bacterial physiology & metabolism
- Composition & structure of prokaryotic cells
- Biosynthetic pathways
- Growth strategies
- Aerobic metabolism of non-glucose substrates
- Anaerobic metabolism
- Chemolithotrophy
- Metabolic pathway prediction
- Fundamentals of metabolic regulation
- Methods of metabolic regulation
- Specific responses to environmental stimuli
- Microbial survival strategies
Coordinator
Dr. Anne Alexander
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