Apr 25, 2024  
2019-2020 Undergraduate Academic Catalog 
    
Catalog Navigation
  Catalog Home
  Academic Calendar
  University Overview
  Enrollment Management Department
  Academic Regulations and Policies
  Student Financial Services
  Academic Departments, Undergraduate Degree Programs, Minors and Certificates
  Degree Programs, Minors and Certificates
  University Scholars Honors Program
  Reserve Officers’ Training Corps. (ROTC)
  English as a Second Language
  Course Descriptions
  Administration, Board of Regents, Faculty and Advisory Committees
  Campus Map
  Student Resources
  My Portfolio
HELP
2019-2020 Undergraduate Academic Catalog [ARCHIVED CATALOG]

Facebook this Page (opens a new window)
Tweet this Page (opens a new window)
Add to Portfolio (opens a new window)

EB 3840 - Bioinformatics III

2 lecture hours 2 lab hours 3 credits
Course Description
Biomolecular misfolding and aggregation, not genetic mutations, is de facto responsible for the vast majority of human diseases. As an extension to the two existing Bioinformatics courses, EB 3420  and EB 3430 , Bioinformatics III will introduce more advanced topics in Bioinformatics, ranging from identification and characterization of sequence and structural motifs implicated in higher-order biomolecular architecture to homology modeling to predict biomolecular 3D structure. In particular, students will learn about how to apply both thermodynamic and comparative algorithms to better understand biomolecular folding mechanisms by which a biosequence folds into its functional 3D structure, efficiently and accurately. In addition, students will learn experientially through collective discussion of most recent journal articles pertinent to contemporary Bioinformatics as well as through effective teamwork to perform lab projects. If time permits, this course will introduce how machine learning can be employed to address biomolecular structure prediction and design active pharmaceutical identities (APIs). (prereq: EB 3430 )
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
  • Understand the complexity of biomolecular 3D structure and its complex intermolecular interactions
  • Understand the implications of biomolecular folding and misfolding
  • Identify and characterize sequence and structural motifs implicated in biomolecular 3D architecture
  • Understand the impact of homology modeling on biomolecular structure prediction
Prerequisites by Topic
  • Biological databases
  • Sequence analysis
Course Topics
  • How a biomolecule folds and why
  • Complexity of higher-order biomolecular structure/assembly
  • Sequence and structural motifs and their roles
  • Biomolecular structure prediction: Homology modeling
  • Drug-receptor interactions: Molecular docking
Coordinator
Dr. Jung Lee


Facebook this Page (opens a new window)
Tweet this Page (opens a new window)
Add to Portfolio (opens a new window)