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Dec 21, 2024
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EB 3810 - Tissue Engineering3 lecture hours 0 lab hours 3 credits
Course Description
This course covers the up-to-date fields of tissue and regenerative engineering, including scaffold design and fabrication, microfabrication technology in tissue engineering, product and process design, and clinical translation of engineered tissues/organs. Topics range from stem cells and embryogenesis, scaffold design and fabrication, organ-on-chips, bioreactors, vascularization, bioprinting, skin tissue engineering, bone/cartilage tissue engineering, cardiovascular tissue engineering, neural tissue engineering, tissue-engineered product manufacturing to clinical translation and ethical issues in tissue and regenerative engineering. (prereq: EB 2250 or equivalent)
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
- Understand the molecular and cellular basis of tissue formation
- Understand various microfabrication technologies in tissue engineering
- Design scaffolds for tissue engineering
- Understand the strategies for tissue engineering in different organ/tissue systems: skin, bone/cartilage, cardiovascular and neural
- Understand and identify the regulatory requirements and ethical issues during clinical translation of tissue engineered products
- Integrate chemistry, biology, and biomaterials to provide potential tissue engineering products to human health problems
Prerequisites by Topic
- Biocompatibility
- Biodegradation
Course Topics
- Cells for tissue engineering
- Clinical grade production of MSCs
- Bioscaffold for tissue engineering
- Scaffold design and fabrication
- Bioreactors for tissue engineering
- Controlled release strategies in tissue engineering
- Tissue fabrication technology: Microfabrication
- Scaffold Design and Fabrication: Organoids and organs-on-a-chip
- Scaffold design and fabrication: Bioprinting
- Scaffold design and fabrication: Decellularization
- Scaffold design and fabrication: Vascularization
- Skin tissue engineering
- Bone and cartilage tissue engineering
- Neural tissue engineering
- Cardiovascular tissue engineering
- Product and process design: Toward industrial TE manufacturing
- Clinical translation of tissue engineering
- Ethical issues in tissue engineering
Coordinator
Dr. Wujie Zhang
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