Feb 01, 2023  
2019-2020 Undergraduate Academic Catalog 
2019-2020 Undergraduate Academic Catalog [ARCHIVED CATALOG]

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EB 3520 - Engineering of Controlled Drug Delivery

2 lecture hours 2 lab hours 3 credits
Course Description
This course addresses the engineering principles behind the development and understanding of controlled drug delivery systems. This course focuses on understanding the drug delivery process and industrial-relevant techniques used for the design of specific formulations. The topics range from general biological barriers to drug delivery and pharmacokinetics to synthetic drug/gene delivery vectors and targeted drug delivery. (prereq: EB 2250 )
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
  • Discuss basic pharmacology, pharmacokinetics and pharmacodynamics
  • Discuss the principles of prodrug design and design prodrugs as drug delivery systems
  • Discuss physiological and chemical barriers for drug delivery
  • Discuss and design the carriers for drug delivery
  • Discuss different controlled drug delivery systems and understand the FDA requirements for controlled release systems; and, be able to design controlled drug delivery systems under the FDA requirements
  • Discuss targeted drug delivery, especially to the brain and tumor; and, be able to design targeted drug delivery systems

Prerequisites by Topic
  • None

Course Topics
  • Introduction to drug delivery
  • Pharmacology, pharmacokinetics and pharmacodynamics
  • Physiological and biochemical barriers to drug delivery
  • Prodrugs as drug delivery
  • Engineered carriers and vectors in drug delivery
  • Diffusion-controlled drug delivery systems
  • Dissolution-controlled drug delivery systems
  • Erodible drug delivery systems
  • Osmotic-controlled drug delivery systems
  • Oral controlled-release delivery
  • Targeting approaches to drug delivery
  • Site-specific drug delivery
  • Bioconjugates and chemical drug delivery
  • Market and FDA requirements for controlled release products

Laboratory Topics
  • Biopolymer purification to achieve pharmaceutical grade
  • Drug stability
  • Alginate-based microcapsules preparation
  • Release profiles of encapsulated drugs

Dr. Wujie Zhang

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