AF 1011 - Foundations of the Air Force 1

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AF 1012 - Foundations of the Air Force 2

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AF 1013 - Foundations of the Air Force 3

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AF 1051 - Leadership Laboratory

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AF 2021 - Evolution of the Air Force/Air and Space Power 1

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AF 2022 - Evolution of the Air Force/Air and Space Power 2

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AF 2023 - Evolution of the Air Force/Air and Space Power 3

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AF 3131 - Air Force Leadership Studies 1

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AF 3132 - Air Force Leadership Studies 2

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AF 3133 - Air Force Leadership Studies 3

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AF 4141 - National Security Affairs/Preparation for Active Duty 1

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AF 4142 - National Security Affairs/Preparation for Active Duty 2

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AF 4143 - National Security Affairs/Preparation for Active Duty 3

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AF 4995 - Independent Study in Air Force and Aerospace Studies

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AR 1001 - Military Physical Training Laboratory 1

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AR 1002 - Military Physical Training Laboratory 2

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AR 1003 - Military Physical Training Laboratory 3

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AR 1100 - Foundations of Officership

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AR 1200 - Basic Leadership 1

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AR 1201 - Basic Leadership 2

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AR 1800 - American Crucible: The Military and the Development of the United States

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AR 2001 - Military Physical Training Laboratory 4

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AR 2002 - Military Physical Training Laboratory 5

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AR 2003 - Military Physical Training Laboratory 6

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AR 2100 - Individual Leadership Studies

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AR 2200 - Leadership and Teamwork 1

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AR 2201 - Leadership and Teamwork 2

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AR 3001 - Military Physical Training Laboratory 7

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AR 3002 - Military Physical Training Laboratory 8

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AR 3003 - Military Physical Training Laboratory 9

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AR 3100 - Leadership and Problem Solving

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AR 3101 - Applied Leadership Laboratory 1

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AR 3200 - Leadership and Ethics 1

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AR 3300 - Leadership and Ethics 2

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AR 3303 - Applied Leadership Laboratory 3

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AR 3964 - Military Science Practicum

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AR 4001 - Military Physical Training Laboratory 10

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AR 4002 - Military Physical Training Laboratory 11

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AR 4003 - Military Physical Training Laboratory 12

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AR 4100 - Officership

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AR 4101 - Advanced Leadership Laboratory 1

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AR 4200 - Leadership and Management 1

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AR 4202 - Advanced Leadership Laboratory 2

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AR 4300 - Leadership and Management 2

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AR 4303 - Advanced Leadership Laboratory 3

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AR 4995 - Independent Study in Military Science and Leadership

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BE 206 - Biomedical Signals and Systems I

• Define and explain terms used to describe first and second order systems
• Formulate differential equations to represent first and second order circuits and selected linear systems. Find the general solution to the DEQ, and use it along with the initial conditions to obtain the solution for transient analysis problems
• Determine the responses of first and second order circuits or systems with stored energy to step inputs using classical time domain techniques
• Formulate and obtain transient solutions to system differential equations using Laplace techniques
• Determine Laplace transforms for impulse, step, exponential and sinusoidal functions
• Transform circuits, including initial conditions, to their equivalent Laplace form and solve the resulting Laplace circuits
• Find inverse Laplace transforms using partial fraction expansion
• Utilize transfer functions to analyze networks and simple linear systems
• Create and interpret frequency response plots and Bode diagrams for linear systems
• Use circuit simulation software to do transient analysis
• Use power supplies, waveform generators, transducers and oscilloscopes to experimentally determine the behavior of circuits and other systems
• Keep a permanent written record of laboratory work
• Write laboratory reports

• DC circuit analysis
• Sinusoidal Steady State AC circuit analysis
• First and Second order linear differential equations
• DC and AC circuit simulation sing Pspice or Mutisim

• Across and through variable elemental relationships for electrical and fluid systems
• Transient analysis of natural and step responses of first order RC and RL networks
• Step responses of RLC networks
• Laplace transforms of functions, mathematical operations and circuit elements
• Circuit analysis in Laplace form
• Inverse Laplace transforms
• Laplace transfer functions
• Sinusoidal steady state transfer functions and Bode Plots

• DC Measurements: using the DC power supply and digital multimeter
• AC measurements: Function generator and oscilloscope introduction
• First Order Electrical System: Long time constant RC circuit
• Second Order Electrical system: Transient response to step input
• Thermal system investigation: Temperature measurement and system analysis using a thermistor
• Multisim or Pspice Transient analysis
• Defibrillator simulation
• Rectangular Pulse and Impulse inputs
• Lab Practical Quiz
• Basic Low-pass/high-pass filters

BE 352 - Survey of Biomedical Engineering

• No course learning outcomes appended

• None

• Human physiology, anatomy, and terminology -particularly that associated with the nervous, cardiovascular, respiratory, and skeletal systems of the body
• Biophysical measurement principles: origin of biophysical signals, how they are measured and clinically interpreted. Particular emphasis will be given to the measurement of: electromyography, electrocardiography, blood pressure, cardiac output, and oxygen saturation
• Electrical and electronic principles associated with transducers, biopotential amplifiers, filters, hospital electronic distribution systems, and electrical safety of medical devices
• Operating principles, clinical applications, and intrinsic hazards associated with a variety of therapeutic medical devices: cardiac defibrillators, pacemakers, intra-aortic balloon pumps, ventricul assist devices, ventilators, x-ray and fluoroscopy machines, nuclear medicine scanners, electrosurgical units, and surgical lasers
• Radiation physics, principles and safety
• Human factors and its application to the control of medical error

BE 410 - Biomaterials

• Describe the structure of solids as they relate to the use of engineering materials
• Describe the mechanical properties of typical engineering materials
• Interpret phase diagram and use them to understand typical material processing procedures such as heat-treatment
• Describe the typical advantages and disadvantages of metals, polymers and ceramics as biomaterials
• Describe specific advantages and disadvantages of 316L stainless steel, cobalt-chrome based alloys, titanium based alloys, polyamides, polyolefins, PVC, PMA, PMMA, hydrogels, thermal plastic polyurethane elastomers, PET, fluorocarbon polymers, silicone elastomers, alumna, silica oxide ceramics, hydroxyapatite and pyrolytic carbon as biomaterials
• Describe typical processing techniques for metals, polymers and ceramic
• Name and describe the general structure and properties of general types of biological structural materials including collagen, elastin and GAG’s
• Describe typical materials used in sutures, artificial heart valves, oxygenator membranes, TAH’s and VAD’s, pacemaker electrodes, dialyzer membranes, contact lens, implantable lens, space filling implants, orthopedic implants, bone cements and dental implants
• Describe the basic principles of tissue engineers and regenerative medicine
• Describe the processes involved in wound healing

• Biochemical terminology, common proteins, common protein structures
• Introductory human biology, anatomy and physiology
• Basic atomic bonding
• Basic thermodynamic principles
• Introductory statics and strength of materials

• Material properties; structure of solids, mechanical properties, corrosion/degradation of materials, and material testing (5 classes)
• Metals; metallic bonding, metallic crystal structure, dislocations, strengthening mechanisms, phase diagrams, phase transformations, corrosion (3 classes)
• Ceramics; bonding and structure, degradation, fracture mechanics, piezoelectric properties, glass ceramics, apatite ceramics, carbon (2 classes)
• Polymers; polymerization process, polymer structure, viscoelastic behavior, degradation (3 classes)
• Composite and textile materials and their properties (3 classes)
• Properties and structure of tissues; collagen, elastin, calcium phosphate, composition and structure of various soft tissues, cortical and cancellous bone, and mechanical properties (3 classes)
• Principles of tissue engineering and regenerative medicine (2 classes)
• Tissue/Material Interaction; biocompatibility, surface properties, ASTM testing standards, effects of artificial materials on the body, effects of the body on artificial materials (2 classes)

BE 411 - Biomechanics

• Define the terms, anatomical axes, and planes associated with human movement
• Understand the physiology associated with skeletal muscle contractions, strength evaluation, joint mechanics, energy requirements, and fatigue
• Understand the principles and use of electromyography as a biomechanics research tool
• Define the design and behavior of the instrumentation, transducers, force plates, etc. used to collect and process human movement data
• Develop 2-D link-segment models from basic anthropometric and kinematic data
• Obtain inverse solutions of joint moments and reaction forces from kinematic and force plate data
• Design and conduct a human-movement based experiment

• Knowledge of engineering statics, dynamics, and strength of materials
• Human physiology and anatomy
• Familiarity with the concepts, instrumentation, and electronics associated with low-level signal amplification, filtering, and processing

• Review of muscle physiology and skeletal anatomy
• Principles and use of electromyography
• Anthropometry
• Center of mass and stability
• Joint motion
• Linear and angular kinematics
• Analysis of kinematic gait data
• Development and use of 2-D link-segment models to estimate joint moments, reaction and compressive forces
• Occupational biomechanics - NIOSH lifting equation, injury mechanisms

• Measurement and use of anthropometic data for the development of link-segment models
• Kinematics and kinetics of elbow flexion
• Vertical jump height and force plates

BE 499 - Clinical Internship

• No course learning outcomes appended

• None

• No course topics appended

BE 1000 - Introduction to Biomedical Engineering

• Describe the general extent and attributes of the biomedical engineering profession
• List and apply the general steps in the engineering design process
• Perform as an effective member of a design team
• Be proficient in the use of basic general and engineering software applications
• Have basic written and oral communications skills
• Maintain an engineering logbook

• None

• Introduction to the biomedical engineering profession and to MSOE’s biomedical engineering program
• Introduction to ethics and professional responsibility in biomedical engineering
• Introduction to the engineering design process
• Maintenance of the engineering logbook and an introduction to time management and time logs
• Introduction to market and competitive products research
• Introduction to intellectual property in engineering design (patents, trademarks, copyrights and trade secrets)
• Introduction to technical and trade literature and literature searches
• Introduction to specifications, requirements validation in design

• Design documentation requirements (incl. engineering logbooks)
• Introduction of design problem
• Team building
• Team design project work (including literature research, market and competitor research, idea generation and selection, prototype design, and testing)

BE 1005 - Introduction to Biomedical Engineering

• Explain the difference between engineering, science and related activities
• Describe general engineering topics applicable to biomedical engineering
• List several biomedical engineering specific topics
• Describe several career options open to biomedical engineering graduates and any additional educational these options require
• Explain the role of regulations and standards in biomedical engineering
• Describe several common medical devices with emphasis on their basic operating principles
• Relate the operating principles of several common medical devices to required course work in MSOE’s biomedical engineering program

• None

• Introduction to the engineering profession in general and biomedical engineering in particular
• Major areas and career options in BE
• Unique aspects of BE (ethical issues, regulatory issues)
• Important aspects of MSOE’s BE program
• Common medical devices and their operating principles
• Introduction to electronics and bioelectric signals
• Introduction to regulation, standard and electrical safety in BE
• Introduction to chemistry and photometrics in biomedical engineering
• Introduction to biophysical transport in biomedical engineering

• Survey of Biomedical Devices
• Medical research field trip (visit to GE, MCW or VA)
• Electronics and Internationals Standards (Simple Circuits & Battery (Bench Equipment) experiment)
• Bioelectric Devices (ECG (Arduino) or EEG (NeuroSky MindWaves) experiment)
• Photometric Medical Devices (Photoplethysmograph (Arduino) experiment)
• Fluidic Devices (Fluid Dynamics or Arterial Pressure Transducer experiment)
• Physical Chemistry Devices (Liquid-Vapor Equilibrium (Arduino)/Respiratory Gas (Biopac) experiment)

BE 2000 - Biomedical Engineering Design I

• No course learning outcomes appended

• Algebra, high school chemistry, english composition

• Design team formation, organization and operation
• Design problem definition
• Identification of customers and customer needs
• Technical literature reviews including the systematic search of trade, medical and engineering literature
• Project budgeting and funding
• Medical device regulation (introduction only)

BE 2200 - MATLAB Programming for Engineers

• Perform computations on scalars and multidimensional arrays from  MATLAB command window
• Create professional-looking plots using MATLAB commands
• Use commands to retrieve data from the user or from input files into the workspace
• Use commands to output data and other information to data file or the command window with appropriate formatting
• Write MATLAB programs that require logical decision making involving un-nested and nested if and switch constructs
• Write MATLAB programs that perform required repetition involving un-nested and nested while and for loops
• Write MATLAB to perform computations and decisions on arrays by using logical arrays and vectorization
• Create MATLAB functions that perform required tasks based on specified data inputs and outputs
• Implement cell arrays and structure arrays in MATLAB code to manage complex data sets
• Predict the outcome of given MATLAB code with specified inputs

• None

• Introduction to MATLAB and its interface (2 lectures)
• Handling variables and basic operations in MATLAB (2 lectures)
• Data input and output (1 lecture)
• Plotting and data visualization (1 lecture)
• Program design (1 lecture)
• Logical operations and selection (4 lectures)
• Repetition (4 lectures)
• Logical arrays and vectorization (2 lectures)
• Creation and use of functions (4 lectures)
• Cell and structure arrays (4 lectures)
• Handles and advanced plotting options (2 lectures)

• Command window computations, script file usage, plotting, basic data i/o, using functions (2 periods)
• Working with large data arrays representing signals using array operations and statistics (2 periods)
• Analyzing biomedical data using branching constructs and loops (2 periods)
• Creating and using functions (2 periods)
• Using cell and structure array concepts to interpret and analyze biomedical imaging files (2 periods)

BE 3000 - Biomedical Engineering Design II

• Apply one or more creative problem solving techniques to their project
• Prepare meaningful technical graphics related to their project
• Evaluate the competitive environment and market for their proposed product
• Evaluate the technical and economic feasibility of their project
• Be prepared for their junior Progress and Feasibility presentation
• Identify the FDA Device Class of their product and understand the implications of this classification
• Use project management techniques and software to plan and manage their project
• Discuss the ethical and regulatory issues involved in experiments using of human and non-human animal subjects

• An overall understanding of the design process, both in general and for the MSOE BME program
• The role of the FDA in medical device regulation
• Design documentation requirements

• Market & Competitive Analyses
• Codes & Standards
• Creative Problem Solving
• CAD and Solid Modeling
• Technical Graphics
• Project Management & Scheduling
• Feasibility Evaluation
• Animal & Human Experimental Subject Ethical and Regulatory Issues

• Team and individual project activities
• 3-D CAD and Solid Modeling

BE 3001 - Biomedical Engineering Design III

• Professionally and persuasively present technical information
• Use appropriate resources in their search for internship opportunities
• Seek external funding for their project work
• Indentify types of engineering prototypes and recognize their value in the design process
• The ability to prepare technical reports and present technical information regarding design efforts
• Discuss the general concept of transducers and indentify transducer requirements for their project
• Find, read, comprehend and apply technical literature related to their project
• Intelligently discuss ethical issues in BE

• Basic understanding of electrical circuit concepts
• An understanding of the overall design process

• Career Services support at MSOE
• Budgets and Project Funding
• Engineering Prototypes
• Common Biomedical Transducers and Their Use
• Finding, Reading & Applying Technical Literature

• Engineering Prototypes - Electrical (creating PC boards, etc.)
• Report writing and presentation techniques
• Instructor’s Choice - Topics as Needed
• Team and Individual Project Activities

BE 3002 - Biomedical Engineering Design IV

• Execute and evaluate system level design
• Develop protocols for system and component level design evaluation
• Describe and apply FDA QSR requirements, particular those related to medical device design and design control
• Plan for and deal with electrical noise in their designs
• Refine their project schedules and planning
• Evaluate and mitigate electrical, mechanical and radiation hazards both in the design process and in their final designs

• Typical junior level electrical and mechanical engineering concepts
• An understanding of the overall design process

• Design - System Level & Embodiment
• Component & System Testing
• Technical Graphics
• FDA QSR & Design Controls
• Electrical Noise and Interference
• Project Management & Scheduling
• Design for Safety and Reliability
• Electrical, Mechanical and Radiation Safety

• Electrical Prototypes (creating PC boards, etc.)
• Electrical Safety
• Mechanical Safety
• Instructor’s Choice - Topics as Needed
• Team and Individual Project Activities

BE 3005 - Professional Topics in BE

• None appended

• None appended

• None appended

BE 3015 - Biomedical Engineering Design I

• No course learning outcomes appended

• None appended

• Design team formation, organization and operation
• Design problem definition
• Identification of customers and customer needs
• Technical literature reviews including the systematic search of trade, medical and engineering literature
• Project budgeting and funding
• Medical device regulation (introduction only)

BE 3100 - Quantitative Systems Physiology I

• Explain the concept of homeostasis, describe the components of a negative feedback loop
• Describe the types of channels, transporters and exchangers that are used to move molecules across membranes
• Explain the importance of membrane potentials, write the electrical analog equation for calculating membrane voltage and use this equation to predict changes in membrane voltage when provided with changes to ion concentrations or membrane conductance
• Explain how cells communicate using electrical and chemical transmission techniques
• Describe the general organization of the nervous system, including the ANS and its divisions
• Identify the main functions of select brain regions
• Explain the role of the nervous system in homeostatic feedback loops
• Discuss the ways that information can be coded within neural circuits
• Compare and contrast skeletal and smooth muscle function and regulation
• Explain/analyze the length-tension curves of muscles
• Describe the anatomical features of the cardiovascular system and explain how these features correlate with function
• Use PV loops to describe and analyze cardiac function
• Use feedback loops to describe the regulation of blood pressure and blood flow
• Interpret a standard ECG tracing

• Cell biology

• Functional organization of the human body (l class)
• Homeostasis, the cell and its function (1 class)
• Diffusion, osmosis and ion transport (2 classes)
• Membrane and action potentials (3 classes)
• Nervous system (4 classes)
• Skeletal muscle contraction and excitation (4 classes)
• Smooth muscle contraction and excitation (1 classes)
• Heart muscle and function (3 classes)
• EKG and cardiac abnormalities (2 classes)
• Circulation and hemodynamics (5 classes)
• Exams (3 classes)

BE 3110 - Quantitative Systems Physiology II

• Describe the components of blood and their functions
• Explain the structure and function of the respiratory system. Predict the operation and control of the respiratory system
• Explain how oxygen is delivered to the blood, carried in the blood, and delivered to the tissues
• Describe how carbon dioxide is carried in the blood and removed by the lung
• Describe how plasma carbon dioxide relates to pH
• Describe the structures and explain the functions of the renal system
• Calculate clearance, renal plasma flow and fractional excretion
• Describe the control of filtration and re-absorption within the renal system
• Describe the role of the kidney in fluid and electrolyte balance
• Apply knowledge of acid-base balance to problems involving gas transport
• Describe the feedback loops in which specified hormones are involved
• Describe energy balance, including the factors that determine energy intake and expenditures
• Describe the organization, function, operation, and control of the selected endocrine system
• Describe the function of the endocrine pancreas and their role in regulating plasma glucose

• Cell biology
• Neuronal function and action potentials

• Lymphatics (1 class)
• Blood (2 classes)
• Mechanics of breathing (3 classes)
• Gas exchange and transport (3 classes)
• Regulation of ventilation (2 classes)
• The kidneys (3 classes)
• Fluid, electrolyte balance and acid base (4 classes)Metabolism and energy balance (4 classes)
• Endocrine control of growth and metabolism (5 classes)
• Exams (3 classes)

BE 3205 - Biomedical Engineering Mechatronics

• Define mechatronics and recognize engineering problems to which mechatronic principles could appropriately be applied
• Decompose complex mechatronic systems into a collection of standard and ad hoc sub-systems
• Systematically select appropriate sensors for specific sensing applications
• Systematically select appropriate actuators for specific applications
• Systematically select appropriate digital controllers for specific mechatronic control applications
• Integrate mechatronic components into a functional system
• Create software to control mechatronic systems

• Electrical quantities and components and linear circuit analysis
• Fundamental quantities and principles of mechanics
• Fundamental programming concepts

• Introduction to Mechatronic Systems, Review of Electrical Fundamentals and Mechanical Fundaments, and Introduction to Digital Electronics (1 week)
• Review of Programming Principles, Embedded Controllers, Single Board Computers, and Communications and Display Options (3 weeks)
• Sensors and Signal Conditioning (2 weeks)
• Actuators and Driving Circuits (2 weeks)
• System Integration and Control (1 week)
• Application Case Studies, Review and Final Projects (1 week)

• None appended

BE 3300 - Biomedical Engineering Transfer Topics

• Apply to and be assigned a position on a design team
• Work effectively as a member of a design team
• Indentify customer needs and translate these into engineering specifications
• Effectively conduct market research and competitive analysis
• Plan, manage and budget
• Describe career option available to BMEs
• Describe the role of the FDA in medical device regulation in the United States
• Maintain design documentation and an engineering logbook
• Search and use the technical literature
• Be able describe the various types of intellectual property
• Use Matlab in the interactive, command mode to solve very simple engineering problems
• Create Matlab scripts (.m files) to solve simple engineering problems
• Analyze existing Matlab programs and understand their operation
• Design, document, implement and test simple Matlab programs to solve biomedical engineering problems
• Correctly use Matlab selection and repetition constructs in programs
• Correctly use Matlab’s advanced data types (complex, strings and cell arrays) in programs
• Read data from and write data to arbitrarily formatted text files in Matlab programs
• Produce professional looking graphics (data plots) using Matlab (both interactively and programmatically)
• Correctly apply z-tests and t-tests
• Perform one- and two-sample inference hypothesis testing
• Evaluate validity and reliability of measurements
• Apply common concepts of experimental and statistical control of error
• Perform analyses of variance
• Develop and apply repeated-measures designs

• An introductory knowledge of biomedical engineering topics
• Proficiency in at least one high level programming language
• Proficiency in basic probability and statistics

• The MSOE BME design process and being a member of a design team
• Specifications and understanding customer needs
• Market research and competitive analysis
• Project planning, management & budgeting
• CAD and Solid Modeling
• Career options for BMEs
• Introduction to FDA
• Design documentation and maintaining an engineering logbook
• Searching the technical literature
• Intellectual property
• Matlab in the interactive, command mode to solve very simple engineering problems
• Matlab scripts (.m files) that solve simple engineering problems
• Designing, documenting, implementing and testing simple Matlab programs
• Matlab selection and repetition constructs
• Matlab’s advanced data types (complex, strings and cell arrays)
• Advanced (formatted) file I/O
• Professional looking graphics (data plots) using Matlab (both interactively and programmatically)
• Correctly applying z-tests and t-tests
• Performing one- and two-sample inference hypothesis testing
• Evaluating validity and reliability of measurements
• Applying common concepts of experimental and statistical control of error
• Performing analyses of variance
• Developing and applying repeated-measures designs

BE 3405 - Biomedical Device Evaluation

• None appended

• None appended

• None appended

BE 3500 - Bio-thermal-fluid Transport I

• Define thermodynamics and give examples of problems that can be solved using thermodynamic principles
• Determine the properties of pure substances using property tables, property diagrams and software
• Use the phase rule to determine the number of degrees of freedom for a non-reacting mixture at equilibrium
• Use phase diagrams, property tables, and software to determine the phases present in a mixture, their relative abundances and the properties of the mixture
• Determine whether the ideal gas equation of state is appropriate for a given system
• Determine the properties of pure ideal gases and mixtures of ideal gases
• State the First Law of thermodynamics and apply it to solve closed system engineering problems and analyze and design steady flow devices relevant to biomedical engineering
• State the Second Law of thermodynamics and use it to determine limits for thermodynamic cycles and assess performance of steady flow devices
• Use psychrometric analysis to define the vapor content of atmospheric air and apply this to air conditioning processes
• Solve fluid flow problems involving the mechanical energy balance and Bernoulli equations
• Define viscosity and describe Newtonian fluid behavior

• Performing single variable integration
• Evaluating and interpreting first partial derivatives

• Thermodynamic definitions; pressure definition and manometry; energy definition and modes of energy transfer (7 classes)
• Properties of pure substances; phases and property diagrams; using property tables and software to determine properties; determination of phase; applying the ideal-gas equation of state (5 classes)
• Boundary work, closed system energy balance, specific heats (4 classes)
• Conservation of mass, flow energy, energy balance application to control volumes and steady flow devices (4 classes)
• Thermodynamic cycles and the second law of thermodynamics; irreversibilities; Carnot cycles and Carnot efficiency (4 classes)
• Entropy; isentropic efficiency for steady flow devices (3 classes)
• Gas mixtures; psychrometrics and analysis of air conditioning processes (3 classes)
• Mechanical energy balance and Bernoulli equation; energy grade lines (3 classes)
• Introduction to fluid phenomena; fluid kinematics (4 classes)
• Exams (3 classes)

BE 3510 - Bio-thermal-fluid Transport 2

• Differentiate between laminar and turbulent flows and describe where each is encountered in the human body
• Apply the concept of flow resistance to solve pipe network problems
• Define the different types of forces that fluid flow imparts on solid bodies and use correlations to estimate these forces for common geometries
• Describe the rheological properties of blood
• Set up classic and biomedical engineering problems using the continuity and Navier-Stokes equations and solve simple cases
• Set up classic and biomedical engineering problems using differential mass and energy balances and solve simple cases
• Apply constitutive relations related to mass diffusion and heat conduction
• Solve simple problems involving conductive heat transfer
• Solve simple problems involving convective heat transfer
• Design heat and mass exchangers to meet specified requirements

• Thermodynamics
• College level Newtonian physics for engineers
• Calculus through ordinary differential equations

• Properties of blood
• Flow in pipes and tubes
• The continuity equation
• Application of the Navier-Stokes equations
• Differential component mass balance
• Mechanisms of heat transfer
• Differential energy balance
• Steady heat conduction
• Lumped system transient heat conduction
• Forced convection
• Heat and mass exchangers

BE 3515 - Bio-thermal-fluid Transport II

• Differentiate between laminar and turbulent flows and describe where each is encountered in the human body
• Apply the concept of flow resistance to solve pipe network problems
• Define the different types of forces that fluid flow imparts on solid bodies and use correlations to estimate these forces for common geometries
• Describe the rheological properties of blood
• Set up classic and biomedical engineering problems using the continuity and Navier-Stokes equations and solve simple cases
• Set up classic and biomedical engineering problems using differential mass and energy balances and solve simple cases
• Apply constitutive relations related to mass diffusion and heat conduction
• Solve simple problems involving conductive heat transfer
• Solve simple problems involving convective heat transfer
• Design heat and mass exchangers to meet specified requirements

• Thermodynamics
• College level Newtonian physics for engineers
• Calculus through ordinary differential equations

• Properties of blood
• Flow in pipes and tubes
• The continuity equation
• Application of the Navier-Stokes equations
• Differential component mass balance
• Mechanisms of heat transfer
• Differential energy balance
• Steady heat conduction
• Lumped system transient heat conduction
• Forced convection
• Heat and mass exchangers

BE 3525 - Survey of Biomedical Engineering

• The ability to describe the general nature of biomedical engineering and its widely recognized application areas
• The ability to describe the roles biomedical engineers typically fulfill in industry and the knowledge and skills associated with these roles
• The ability to explain major general principles of physiology, anatomy and pathology topics related to biomedical engineering using appropriate vocabulary
• The ability to describe the intrinsic hazards associated with common medical devices and the implications of these hazards in biomedical engineering
• The ability to describe ethical and legal issues that impact biomedical engineering
• The ability to describe regulatory and documentation issues involved in biomedical engineering
• The ability to explain the basic operating principles of some common medical devices
• The ability to describe the role of human factors in the control of medical errors and accidents
• The ability to discuss predictions regarding the future of heath care and biomedical engineering

• TBD

• TBD

BE 3600 - Biomedical Instrumentation

• Utilize transducers in the measurement of physiological signals of medical interest
• Design basic electronic circuitry using operational amplifiers to amplify the signals produced by resistive pressure, flow and displacement transducers
• Predict and test the dynamic performance of fluid systems used for blood pressure measurement
• Design basic passive filters and 2nd order active filters to process signals
• Predict the overall performance of cascaded processing modules
• Design circuitry to generate periodic voltage or current waveforms
• Assess the stability of feedback systems with respect to oscillation
• Assess the effect of non-ideal operational amplifier properties on circuit performance
• Use circuit simulation programs to design and test circuits and model fluid systems

• AC, DC, and transient circuit analysis in the time domain
• AC, DC, and transient circuit simulation using Pspice or Multisim
• Laplace circuit analysis
• Bode plots
• Ability to conduct laboratory experiments using function generators, power supplies, multi-meters and oscilloscopes

• Amplification concepts using simple 3-element models: cascading and loading effects
• Amplifier implementation using operational amplifiers: inverting, non-inverting, summing amplifiers
• Difference amplifiers and fundamentals of instrumentation amplifiers
• Linear and angular displacement transducers and blood pressure transducers
• First and second order filters implemented with op amps, low pass, high pass and band pass
• Analysis of fluid system based on a blood pressure transducer and catheter tubing
• Static non-ideal op amp characteristics: offset voltages and bias currents, finite gain and input and output resistances
• Dynamic non-ideal op amp characteristics: finite bandwidth, frequency response and slew rate
• Stability of feedback amplifiers
• Positive feedback, hysteresis, and relaxation oscillators

• Introduction to amplifier concepts using dependent sources and a circuit simulation program
• Design and implementation of basic amplifiers using op amps
• Electrical measurement of angles; goniometer simulation
• Design and implementation of a blood pressure transducer amplifier using an instrumentation amplifier
• Filtering an ECG waveform containing typical interference found in the laboratory setting (2wks)
• Dynamic analysis and testing of a blood pressure transducer and tubing system (2wks)
• Investigation of non-ideal operational amplifier characteristics
• Linear, sinusoidal oscillator or relaxation oscillator design and implementation

BE 3705 - Biomedical Electronics and Instrumentation

• Utilize transducers in the measurement of physiological signals of medical interest
• Design basic electronic circuitry using operational amplifiers to amplify the signals produced by resistive pressure, flow and displacement transducers
• Predict and test the dynamic performance of fluid systems used for blood pressure measurement
• Design basic passive filters and 2nd order active filters to process signals
• Predict the overall performance of cascaded processing modules
• Design circuitry to generate periodic voltage or current waveforms
• Assess the stability of feedback systems with respect to oscillation
• Assess the effect of non-ideal operational amplifier properties on circuit performance
• Use circuit simulation programs to design and test circuits and model fluid systems

• AC, DC, and transient circuit analysis in the time domain
• AC, DC, and transient circuit simulation using Pspice or Multisim
• Laplace circuit analysis
• Bode plots
• Ability to conduct laboratory experiments using function generators, power supplies, multi-meters and oscilloscopes

• Amplification concepts using simple 3-element models: cascading and loading effects
• Amplifier implementation using operational amplifiers: inverting, non-inverting, summing amplifiers
• Difference amplifiers and fundamentals of instrumentation amplifiers
• Linear and angular displacement transducers and blood pressure transducers
• First and second order filters implemented with op amps, low pass, high pass and band pass
• Analysis of fluid system based on a blood pressure transducer and catheter tubing
• Static non-ideal op amp characteristics: offset voltages and bias currents, finite gain and input and output resistances
• Dynamic non-ideal op amp characteristics: finite bandwidth, frequency response and slew rate
• Stability of feedback amplifiers
• Positive feedback, hysteresis, and relaxation oscillators

• Introduction to amplifier concepts using dependent sources and a circuit simulation program
• Design and implementation of basic amplifiers using op amps
• Electrical measurement of angles; goniometer simulation
• Design and implementation of a blood pressure transducer amplifier using an instrumentation amplifier
• Filtering an ECG waveform containing typical interference found in the laboratory setting (2wks)
• Dynamic analysis and testing of a blood pressure transducer and tubing system (2wks)
• Investigation of non-ideal operational amplifier characteristics
• Linear, sinusoidal oscillator or relaxation oscillator design and implementation

BE 3800 - Biomedical Signals and Systems II

• Explain the difference between intrinsic and extrinsic biological signals
• Explain the difference between the Fourier series and Fourier transform
• Analyze a continuous-time, periodic signal and represent that signal as a sum of weighted complex exponentials or sinusoids by computing its Fourier series coefficients
• Reconstruct a continuous-time signal from its Fourier series coefficients
• Determine the Fourier transform (or inverse Fourier transform) of a signal by using a table of common Fourier transform pairs and a table of Fourier transform properties
• Determine and plot the magnitude and phase spectra of a continuous-time signal using the Fourier transform
• Determine the bandwidth of a continuous-time signal
• Develop the transfer function for a continuous linear time invariant (LTI) system
• Determine the frequency response of a LTI System
• Design an analog filter to approximate the frequency response of an ideal filter (lowpass, bandpass, bandstop, or highpass)
• Use MATLAB as an engineering tool
• Compute the output of a linear, time-invariant (LTI) system using the convolution integral
• Compute the power and/or energy of a continuous-time signal and/or an LTI system

• None 

• Introduction course requirements, expected outcomes (1 class)
• Define signals and systems (1 class)
• Review of Matlab and Multisim ((1 class)
• Review of complex numbers and complex exponentials (2 classes)
• Power and Energy in a system with multiple sources at the same and at different frequencies (3 classes)
• Exponential Fourier Series (3 classes)
• Fourier Series Coefficients and Insights (3 classes)
• Continuous-Time Signals, LTI Systems, and Convolution (3 classes)
• Frequency Response(3 classes)
• Continuous-Time Fourier Transform (6 classes)
• Exams and Assessment (4 classes)

BE 3900 - Physiology and Bio-System Joint Laboratory

• Apply principles of membrane potentials to write the electrical analog equation for calculating membrane voltage and use this equation to predict changes in membrane voltage when provided with changes to ion concentrations or conductances
• Measure physiological parameters, analyze the results of those measurements, and correlate the resulting analysis to concepts found in biomedical signals and systems
• Use physiological measurements to evaluate the relationship between the Fourier series and the Fourier transform
• Analyze a physiological system for its stability, response to a stimulus, and predict the response

• None

• No course topics appended

BE 3905 - Biomedical Combined Laboratory I

• Apply principles of membrane potentials to write the electrical analog equation for calculating membrane voltage and use this equation to predict changes in membrane voltage when provided with changes to ion concentrations or conductances
• Measure physiological parameters, analyze the results of those measurements, and correlate the resulting analysis to concepts found in biomedical signals and systems
• Use physiological measurements to evaluate the relationship between the Fourier series and the Fourier transform
• Analyze a physiological system for its stability, response to a stimulus, and predict the response

• No prerequisites by topic appended

• No course topics appended

• No laboratory topics appended

BE 3910 - Physiology and Biotransport Joint Laboratory

• Use tools to measure liquid viscosity, flow rate and pressure
• Manipulate fluid systems involving pumps
• Use computer models to determine parameters of experimental fluid and mass transfer systems
• Evaluate the applicability of analytical, experimental and numerical models
• Experimentally test hypotheses related to pulmonary function
• Design experiments to evaluate the nature and effectiveness of different modes of convective heat transfer

• Thermodynamics and heat transfer
• Fluid mechanics based on differential analysis
• Mass transfer and permeability
• Computer programming using MATLAB
• Calculus through ordinary differential equations

• No course topics appended

• Rheological properties and viscosity measurement
• Instruments of fluid systems
• Computational fluid dynamics using commercial software
• Pulmonary function testing
• Multi-compartment modeling
• Measurement of convective heat transfer

BE 3915 - Combined Lab II: Physiology, DSP & Biomechanics

• Demonstrate proficiency in applying fundamental signal processing methodologies to analyze biomedical signals with a goal to extract system-specific pertinent information
• Demonstrate proficiency in applying the appropriate statistics and interpreting their results when analyzing biomedical signals and systems
• Demonstrate proficiency in using MATLAB (and/or other appropriate computer-aided tools) to analyze biomedical signals and systems, and for biomedical system modeling
• Demonstrate an ability to solve specific biomedical problems using multidisciplinary approach
• Demonstrate an ability to function on multidisciplinary teams  
• Demonstrate proficiency to document engineering and experimental work

• Sampling
• Discrete Fourier Analysis
• Digital Filtering
• Digital System Analysis

• Review of cardiovascular physiology
• Physiological origins of electrocardiographic (ECG) and other electrical cardiac signals
• Overview of neuroanatomy and neurophysiology
• Physiological origins of electroencephalographic (EEG) and other electrical neuro-signals
• Review of joints and muscular system physiology
• Physiological origins of electromyographic (EMG) and other related signals
• Introduction to biomechanics and human movement
• Anthropometry
• Linear and angular kinematics
• Force plates
• Occupational biomechanics

• Analysis of the EEG and local field potentials signals using appropriate signal processing methods
• Hudgkin and Hoxley neuronal conductance-based model simulation
• Windkassel aortic flow model simulation  
• Analysis of ECG, cardiac electrogram, blood pressure, and cardiac cellular signals using appropriate signal processing methods
• Analysis of EMG signals using appropriate signal processing methods
• Biomechanics modeling and simulation
• Anthropometry
• Kinematics and kinetics of elbow flexion
• Center of pressure and stability of stance

BE 3920 - Biomaterials and Biomechanics Joint Laboratory

• Make anthropometric measurements
• Perform kinematic and kinetic measurements and analyses of a human joint or joints
• Take and analyze force plat data
• Use Numerical Finite Element Method (FEM) modeling software to perform mechanical, thermal and Computational Fluid Dynamic (CFD) biomedical engineering related analyses
• Understand practical manufacturing issues associated with common biomaterials
• Present biomaterials and/or biomechanics related technical information in a professional manor

• Basic engineering statics, dynamics and strength of materials
• Basic biology and physiology

• Anthropometric measurements
• Kinematic and kinetic joint measurements
• Force plate measurements
• Mechanical, thermal, electrical and Computational Fluid Dynamics (CFD) analysis of situations of biomedical engineering interest using numerical Finite Element Method (FEM) software
• Manufacturing plant visit
• Biomaterials and/or biomechanics technical presentations

• Anthropometric Measurements and Analysis
• Kinematic and Kinetic Measurements and Analysis
• Force Plate Measurements and Analysis
• Mechanical, thermal, electrical and Computational Fluid Dynamics (CFD) analysis of situations of biomedical engineering interest using numerical Finite Element Method (FEM) software
• Manufacturing Plant Visit
• Biomaterials and/or biomechanics technical presentations

BE 4000 - Biomedical Engineering Design V

• Describe important current topics and trends in BE
• Use appropriate resources to conduct their search for employment or graduate study opportunities
• Describe the special requirements associated with medical device software
• Describe the clinical evaluation process for medical devices
• Explain the importance of professional licensure and the process for obtaining licensure
• Describe the scope and applicability of various common accreditations, codes, and standards (such as JCAHO, NFPA, NEC, AAMI, ANSI) in BME practice
• Appropriately consider usability and maintainability issues during the design process
• Plan for and deal with electrical noise and interference in their designs
• Be able to “sell” their ideas

• Typical senior level electrical and mechanical engineering concepts
• An understanding of the overall design process

• Current Topics and Trends in BE
• Employment Search Resources and Techniques
• Graduate School & Grad School Applications
• Professional Licensure
• Software for Medical Devices
• Clinical Evaluation of Medical Devices
• JCAHO, NFPA, NEC, AAMI, ANSI, etc.
• Design for Maintainability and Design for Usability
• Electrical Noise and Interference
• Technical Persuasion (“Selling” your ideas and products)

• Design Reviews
• Instructor’s Choice - Topics as Needed
• Team and Individual Project Activities

BE 4001 - Biomedical Engineering Design VI

• Describe and discuss current topics and trends in BE
• Discuss various approaches to protecting and profiting from intellectual property including the typical advantages and disadvantages of each approach
• Apply engineering economics as appropriate for the Fundamentals of Engineering examination
• Make a persuasive technical argument and ultimately “sell” an idea or product
• Understand common manufacturing and assembly processes and state where these are applicable to their design
• Consider manufacturing issues in their design process
• Be able calculate power requirements and select appropriate power supplies and/or batteries for their design project
• Summarize modern statistical concepts in diagnostic testing and appropriately apply them to their design project

• Typical senior level electrical and mechanical engineering concepts
• An understanding of the overall design process

• Current Topics and Trends in BE
• Manufacture and Device Assembly Processes
• Design for Manufacturing
• Power Budgets, Power Supplies and Batteries
• Intellectual Property
• Engineering Economics
• Statistical Concepts in Diagnostic Testing
• Technical Persuasion

• Design Reviews
• Instructor’s Choice - Topics as Needed
• Team and Individual Project Activities

BE 4002 - Biomedical Engineering Design VII

• Describe and discuss the current topics and tend in BE
• Explain current manufacturing and assembly processes and select and apply these to their design projects
• Be able address biological safety concerns and to describe and select sterilization and infection control processes
• Document the outcome of their design process
• Be prepared to present the results of their design efforts to the BE program faculty and the public

• Typical senior level electrical and mechanical engineering concepts
• An understanding of the overall design process

• Current Topics and Trends in BE
• Senior Design Show Briefing (posters, final documents and interactions)
• Ethics in Biomedical Engineering (incl. Case Studies)
• Manufacture and Assembly Processes
• Sterilization, Infection Control & Biological Safety

• Instructor’s Choice - Topics as Needed
• Team and Individual Project Activities

BE 4005 - Biomedical Engineering Design II

• Describe important current topics and trends in BE
• Use appropriate resources to conduct their search for employment or graduate study opportunities
• Describe the special requirements associated with medical device software
• Describe the clinical evaluation process for medical devices
• Explain the importance of professional licensure and the process for obtaining licensure
• Describe the scope and applicability of various common accreditations, codes, and standards (such as JCAHO, NFPA, NEC, AAMI, ANSI) in BME practice
• Appropriately consider usability and maintainability issues during the design process
• Plan for and deal with electrical noise and interference in their designs

• Senior level electrical and mechanical bioengineering concepts
• An understanding of the overall design process

• Current Topics and Trends in BE
• Employment Search Resources and Techniques
• Graduate School & Grad School Applications
• Professional Licensure
• Software for Medical Devices
• Clinical Evaluation of Medical Devices
• JCAHO, NFPA, NEC, AAMI, ANSI, etc.
• Design for Maintainability and Design for Usability
• Electrical Noise and Interference
• Technical Persuasion (“Selling” your ideas and products)

• Design Reviews
• Instructor’s Choice - Topics as Needed
• Team and Individual Project Activities

BE 4015 - Biomedical Engineering Design III

• Describe and discuss current topics and trends in BE
• Discuss various approaches to protecting and profiting from intellectual property including the typical advantages and disadvantages of each approach
• Apply engineering economics as appropriate for the Fundamentals of Engineering examination
• Make a persuasive technical argument and ultimately “sell” an idea or product
• Understand common manufacturing and assembly processes and state where these are applicable to their design
• Consider manufacturing issues in their design process
• Calculate power requirements and select appropriate power supplies and/or batteries for their design project
• Summarize modern statistical concepts in diagnostic testing and appropriately apply them to their design project

• Senior level electrical and mechanical bioengineering concepts
• An understanding of the overall design process

• Current Topics and Trends in BE
• Manufacture and Device Assembly Processes
• Design for Manufacturing
• Power Budgets, Power Supplies and Batteries
• Intellectual Property
• Engineering Economics
• Statistical Concepts in Diagnostic Testing
• Technical Persuasion

• Design Reviews
• Instructor’s Choice - Topics as Needed
• Team and Individual Project Activities

BE 4025 - Biomedical Engineering Design IV

• Describe and discuss the current topics and tend in BE
• Explain current manufacturing and assembly processes and select and apply these to their design projects
• Address biological safety concerns and to describe and select sterilization and infection control processes
• Document the outcome of their design process
• Present the results of their design efforts to the BE program faculty and the public

• Senior level electrical and mechanical bioengineering concepts
• An understanding of the overall design process

• Current Topics and Trends in BE
• Senior Design Show Briefing (posters, final documents and interactions)
• Ethics in Biomedical Engineering (incl. Case Studies)
• Manufacture and Assembly Processes
• Sterilization, Infection Control & Biological Safety

• Instructor’s Choice - Topics as Needed
• Team and Individual Project Activities

BE 4205 - Medical Imaging Systems

• Demonstrate an understanding of fundamental concepts related to radiation physics
• Demonstrate an understanding of general image characteristics across all imaging modalities
• Demonstrate an understanding of how a basic x-ray system works and how images are created
• Demonstrate an understanding of how a basic CT system works and how images are created
• Demonstrate an understanding of how a basic MRI system works and how images are created
• Demonstrate an understanding of how a basic ultrasound system works and how images are created
• Demonstrate an understanding of how a basic PET (and/or other nuclear medicine systems) works and how images are created
• Proficiently apply fundamental image processing techniques to medical images
• Demonstrate an understanding of the ethical dilemmas in the medical imaging field
• Proficiently apply MATLAB (or other computer-aided tools) to perform image analysis

• Ability to write computer programs
• Ability to apply convolution and perform data filtering
• Ability to understand and apply Discrete Fourier Transforms
• Ability to use MATLAB

• Overview of imaging modalities
• Image characteristics
• Image processing techniques
• Fundamentals of radiation physics
• Imaging formation using x-ray
• X-ray imaging systems
• Computer Tomography systems
• Magnetic Resonance systems
• Nuclear Imaging (emphasis on Positron Emission Tomography)
• Ultrasound imaging

• Image visualization and display
• Image processing basics (filtering, edge detection, etc.)
• 2D spatial frequency spectrum
• Digital subtraction angiography
• Filtered backprojection
• Image segmentation
• Image registration

BE 4340 - Advanced Topics in Biomedical Digital Signal Processing

• Possess advanced skills in digital signal processing necessary to function as a successful biomedical engineer, whose role involves quantitative analysis of biological signals
• Implement using computer tools specific advanced signal processing methodologies that are commonly used for extraction of clinically relevant information from biological signals
• Understand the challenges of digital signal processing when applied to the analysis of various biological signals

• Continuous and discrete signals and systems concepts
• Continuous and discrete Fourier Transform and Series
• Sampling, aliasing, and spectral replication
• Fast Fourier Transform
• A/D conversion and quantization concepts
• Digital filters (FIR and IIR) and digital filter design fundamentals
• Z-Transforms and Unit Circle concepts
• Statistical analysis
• Proficiency in MATLAB programming

• Review of fundamental digital signal processing concepts such as sampling, aliasing, and Discrete Fourier Transform and Series (2 classes)
• Overview of random (single) processes, stationarity, ergodicity and autocorrelation concepts (4 classes)
• Standard methodologies of power spectral estimation such as Welch Periodogram and Blackman Tukey (4 classes)
• Introduction of joint random processes, covariance and cross-correlation measures (4 classes)
• Cross-spectral estimation and coherence (4 classes)
• Introduction to time-frequency analysis. Short-Segment Fast Fourier Transform (4 classes)
• Bi-weekly quizzes (2 classes total)

• No laboratory. However, the students will be responsible for take-home computer projects involving the implementation of various signal processing methodologies and their application to the analysis of specific biological signals. The students will be required to submit a formal report

BE 4700 - Biomedical Electronics

• Quantitatively predict electrical field distribution for simple geometries in a 3-dimensional body
• Design, construct and test prototype circuits to detect and process electrical signals produced by the body
• Account for the electrical behavior of electrodes in recording biopotentials
• Recognize and mitigate the interference and noise in recording biological signals
• Convert signals between digital and analog forms
• Calculate lung volumes and respiratory system parameters from pulmonary function tests data
• Employ circuit simulation in the analysis and design of medical instrumentation

• Electronics: transistors and op amps
• Physiology of nerves, muscles, and the respiratory system
• Circuit simulation using Pspice or Multisim
• Chemistry

• Biopotentials and the electrical behavior of biopotential electrodes
• Voltage and current distribution in tissue from point, cylindrical and flat surfaces
• ECG amplifier design
• DC offset, common mode and high frequency interference in biopotential amplifier design and recording
• Intrinsic noise: primarily thermal and 1/f noise in low level amplifiers
• Analog to digital and digital to analog conversion
• Respiratory system testing: basic tests of lung volumes and respiratory mechanics

• Electrical Interference Investigation
• Measurement of current and voltage in biological media
• ECG amplifier design project
• Intrinsic noise investigation
• Analog to digital and digital to analog conversion
• Biological signal processing: Alpha wave detector

BE 4705 - Biomedical Electronics and Instrumentation II

• Quantitatively predict electrical field distribution for simple geometries in a 3-dimensional body
• Design, construct and test prototype circuits to detect and process electrical signals produced by the body
• Account for the electrical behavior of electrodes in recording biopotentials
• Recognize and mitigate the interference and noise in recording biological signals
• Convert signals between digital and analog forms
• Calculate lung volumes and respiratory system parameters from pulmonary function tests data
• Employ circuit simulation in the analysis and design of medical instrumentation

• Electronics: transistors and op amps
• Physiology of nerves, muscles, and the respiratory system
• Circuit simulation using Pspice or Multisim
• Chemistry

• Biopotentials and the electrical behavior of biopotential electrodes
• Voltage and current distribution in tissue from point, cylindrical and flat surfaces
• ECG amplifier design
• DC offset, common mode and high frequency interference in biopotential amplifier design and recording
• Intrinsic noise: primarily thermal and 1/f noise in low level amplifiers
• Analog to digital and digital to analog conversion
• Respiratory system testing: basic tests of lung volumes and respiratory mechanics

• Electrical Interference Investigation
• Measurement of current and voltage in biological media
• ECG amplifier design project
• Intrinsic noise investigation
• Analog to digital and digital to analog conversion
• Biological signal processing: Alpha wave detector

BE 4800 - Biomedical Digital Signal Processing

• Possess the skills necessary to function as an entry level biomedical engineer in biomedical signal processing. This includes understanding common signal processing methods and understanding the advantages and disadvantages of digital signal processing in analyzing biological signals
• Implement using software tools, common signal processing methods on a range of biological signals. Example software tools include MATLAB
• Understand sampling and quantization such that they can specify instrumentation and procedures for digitally recording biological data

• Understand the characteristics of common biopotential signals. Understand the origin of biopotentials, and how these signals can be coupled to analog circuitry. Understand Laplace and Fourier transforms. Have a working knowledge of computer programming

• Review of continuous signal and system concepts (2 classes)
• Signal sampling, aliasing, and spectral replication (3 classes)
• Discrete Fourier Series and Discrete Fourier Transforms (3 classes)
• Spectral calculations, spectral leakage, and windowing (3 classes)
• A/D conversion (1 class)
• Digital filtering: time and frequency domain analysis of FIR and IIR filters (1 class)
• Z-Transforms and digital filters (1 class)
• Two exams (2 classes)

• Investigating the effects of proper and improper sampling on signal characteristics
• Investigating the effects of spectral leakage and windowing on signal characteristics
• Power spectral analysis of biological signals with and without windowing
• Digital filter implementation and frequency analysis
• Digital filtering of biological signals and their spectral representation

BE 4805 - Biomedical System Dynamics

• Develop models of mechanical, electrical, fluid thermal and biological systems in the frequency domain and in the time domain
• Develop the transfer function for linear time-invariant (LTI) electrical, mechanical, fluid, thermal, and biological systems
• Model a LTI systems in state-variable form
• Solve for the time-domain response (impulse, step, ramp) of first and second order feedback transfer functions
• Write the transfer function of first and second order feedback control systems
• Solve for the stability factors and system error for LTI control systems
• Use MATLAB to analyze feedback control systems

• Be able to represent continuous and discrete signals in the time-domain
• Be able to represent continuous and discrete signals in the frequency-domain
• An understanding of linear electronic systems
• The ability to apply Feedback Control to the Engineering Design Process

• Introduction and course expectations (1 class)
• Modeling of the components of mechanical, electrical, fluid thermal and biological systems (6 classes)
• Introduction to feedback control systems (1 class)
• Models of physical systems (3 classes)
• State-Variable Models (3 classes)
• Models of biological systems with state variables (2 classes)
• Linear time-invariant system responses (4 classes)
• Closed loop Control linear time-invariant systems - Stability and Sensitivity (6 classes)
• Analysis and design of biomedical engineering systems (2 classes)
• Exams (2 classes)

BE 4810 - Biomedical Feedback Control Systems I

• Develop models of mechanical, electrical (including ideal operational amplifiers), fluid thermal and biological systems in the frequency domain and in the time domain
• Develop the transfer function for linear time-invariant (LTI) electrical, mechanical, fluid, thermal, and biological systems
• Model a LTI systems in state-variable form
• Solve for the time-domain response (impulse, step, ramp) of first and second order feedback transfer functions
• Write the transfer function of first and second order feedback control systems
• Solve for the stability factors and system error for LTI control systems
• Use MATLAB to analyze feedback control systems

• Be able to represent continuous and discrete signals in the time-domain
• Be able to represent continuous and discrete signals in the frequency-domain
• An understanding of Human Anatomy and Physiology
• An understanding of linear and non-linear electronic systems
• An understanding of Biophysical Transport processes
• The ability to apply Feedback Control to the Engineering Design Process

• Introduction and course expectations (1 class)
• Modeling of the components of mechanical, electrical (including ideal operational amplifiers), fluid thermal and biological systems (6 classes)
• Introduction to feedback control systems (1 class)
• Models of physical systems (3 classes)
• State-Variable Models (3 classes)
• Models of biological systems with state variables (2 classes)
• Linear time-invariant system responses (4 classes)
• Closed loop Control linear time-invariant systems - Stability and Sensitivity (6 classes)
• Analysis and design of biomedical engineering systems (2 classes)
• Exams (2 classes)

BE 4815 - Biomedical Feedback Control Systems

• Solve for system stability using Routh-Hurwitz Stability Criterion
• Use Root-Locus and Frequency Domain techniques to analyze and design first and second order LTI feedback control systems
• Use Root-Locus technique to analyze and design first and second order LTI feedback control systems
• Apply knowledge of classical analog feedback control theory in the laboratory
• Design PI, PD, and PID controllers to be used in first and second order systems
• Investigate using neural signals as control inputs
• Use MATLAB and Simulink to analyze and design feedback control systems

• Develop models of mechanical, electrical (including ideal operational amplifiers), fluid thermal and biological systems in the frequency domain and in the time domain
• Develop the transfer function for linear time-invariant (LTI) electrical, mechanical, fluid, thermal, and biological systems
• Model a LTI systems in state-variable form
• Solve for the time-domain response (impulse, step, ramp) of first and second order feedback transfer functions
• Write the transfer function of first and second order feedback control systems
• Solve for the stability factors and system error for LTI control system
• Use MATLAB to analyze feedback control systems

• Introductory Material (1 class)
• Stability analysis Routh- Hurwitz (4 classes)
• Root-Locus analysis and design (6 classes)
• Frequency-Response Analysis and Design (6 classes)
• State Space Based Control (4 classes)
• Brain Machine Interfaces (6 classes)
• Examinations and Review (3 classes)

BE 4820 - Biomedical Feedback Control Systems II

• Solve for system stability using Routh-Hurwitz Stability Criterion
• Use Root-Locus and Frequency Domain techniques to analyze and design first and second order LTI feedback control systems
• Use Root-Locus technique to analyze and design first and second order LTI feedback control systems
• Apply knowledge of classical analog feedback control theory in the laboratory
• Design PI, PD, and PID controllers to be used in first and second order systems
• Investigate using neural signals as control inputs
• Use MATLAB and Simulink to analyze and design feedback control systems

• Develop models of mechanical, electrical (including ideal operational amplifiers), fluid thermal and biological systems in the frequency domain and in the time domain
• Develop the transfer function for linear time-invariant (LTI) electrical, mechanical, fluid, thermal, and biological systems
• Model a LTI systems in state-variable form
• Solve for the time-domain response (impulse, step, ramp) of first and second order feedback transfer functions
• Write the transfer function of first and second order feedback control systems
• Solve for the stability factors and system error for LTI control system
• Use MATLAB to analyze feedback control systems

• Introductory Material (1 class)
• Stability analysis Routh- Hurwitz (4 classes)
• Root-Locus analysis and design (6 classes)
• Frequency-Response Analysis and Design (6 classes)
• State Space Based Control (4 classes)
• Brain Machine Interfaces (6 classes)
• Examinations and Review (3 classes)

• Review Final Examination given in BE-4810 and general questions
• Dynamic System Simulation Using Simulink
• PI, PD, and PID Compensator Design, Construct and Test
• Modeling and Control of a Servomotor
• Neural Cursor Control

BE 4830 - Medical Imaging Systems

• Possess the skills necessary to function in an entry level biomedical engineer in medical imaging. This includes understanding how an image is created in each of the major imaging modalities including x-ray, computed tomography, magnetic resonance, nuclear imaging, and ultrasound. This also includes being familiar with overall system design for imaging systems in each of the major imaging modalities and being familiar with common medical imaging algorithms implemented in imaging system software
• Implement using software tools, common image processing methods. Example software tools include MATLAB
• Have team practice in presenting technical information in a written manner of a professional

• Ability to apply time and frequency convolution
• Ability to understand and apply Fourier Series and Fourier Transforms
• Ability to understand and apply basic concepts in digital signal processing

• Overview of all imaging modalities, their history, and contemporary clinical applications (3 classes)
• Image processing (1 class)
• Radiation (2 classes)
• X-ray imaging and fluoroscopy (4 classes)
• Computed tomography (3 classes)
• Magnetic resonance imaging (4 classes)
• Nuclear imaging including PET and SPECT (3 classes)
• Ultrasound (4 classes)
• Emerging imaging modalities (3 classes)
• Five quizzes and discussion of quizzes (3 classes)
• Review and in-class image processing assignments (1 class)
• Guest speakers (2 classes)

• At least two take-home image processing assignments will be given, dealing with image processing of CT and PET images in standard DICOM format. The projects will involve the standard normalization, display and post-processing of medical images, typically performed in clinical practice. The students will have an opportunity to implement image processing techniques such as Maximum Intensity Projections, image segmentation, image filtering, and others

BE 4980 - Independent Study

• Varies

• Varies

• Varies

• Varies

BE 4990 - BE Special Topics

• No course learning outcomes appended

• Varies

• No course topics appended

BI 102 - Cell Biology and Genetics

• Be able to describe the general structure and correlate the chemical properties of atoms and molecules
• Be able to describe the structural and functional properties of the macromolecules found in living matter
• Be able to list the structural components of mammalian cells and explain their function
• Be able to list the types of transport processes occurring across the cell membranes and the energy sources for them
• Be able to explain the mechanisms of intercellular communication
• Be able to identify the enzyme’s structural domains important for the chemical kinetics
• Be able to describe the mechanisms of energy storage, transfer, release and use in cellular processes
• Be able to describe the processes of mitosis and meiosis and conditions under which they occur
• Be able to define the genetic terms and solve traditional genetic problems
• Be able to describe the processes of transcription and translation, including their regulation, and discuss their effect on the cell function
• Be able to explain how changes in genetic material can occur
• Be able to describe the major techniques involved in gene technology and describe specific uses of each technique
• Be able to design and perform a scientific experiment, including hypothesis generation and testing
• Be able to explain the use of statistical tests to interpret laboratory data
• Be able to write a scientific report in standardized format

• One year of high school chemistry

• Chemical context of life and its environment
• Structure and function of macromolecules
• Cell structure, function, metabolism and communication
• Cell cycle, mitosis and meiosis
• Genetics and inheritance
• Transcription, translation and their control
• Altering the genetic message
• Gene technology
• Exams

• Computer usage for data collectionand report writing
• Experimental design and report writing
• Microscopes and cell imaging
• Enzymatic activity
• Osmosis
• Geneticc

BI 172 - Human Anatomy and Physiology I

• Explain the concepts of homeostasis and positive and negative feedback
• Understand the terminology related to anatomical orientation, body regions and body cavities
• List the classes and explain the histological features of tissues
• Explain the histological structure and functions of the integumentary system
• Explain the histological features and functions of bones
• Name and locate the major bones of the human body
• Define the names of the important surface features of bones
• Explain the classifications of joints and the standard features of synovial joints
• Name and locate the major muscles of the human body
• Understand the terminology used to name muscles
• Explain the histological features and functions of nervous tissue
• Name, locate and describe the function of the major features of the central nervous system
• Describe the functions of the various nervous systems

• Cell biology and genetics

• Homeostasis and general orientation to anatomy (2 classes)
• Histology (2 classes)
• Integumentary system (2 classes)
• Bone tissue, skeletal system and joints (7 classes)
• Muscular tissue and muscular system (7 classes)
• Nervous tissue and central nervous system (7 classes)
• Exams (3 classes)

BI 256 - Microbiology

• Describe the general characteristics, size and cellular organization of microorganisms
• Know the elements of microbial nutrition, growth and metabolism and the environmental influences affecting growth and metabolism
• Understand the host defense mechanisms important for fighting microbial infections
• Understand how common microbial diseases are diagnosed
• Understand the basics of microbial epidemiology and infection control
• Know the major infectious diseases and their routes of infection
• Know the laboratory steps and techniques routinely involved in specimen preparation, staining and in the culture of certain microorganisms
• Understand how to do a proper literature review and library search for journal articles

• Cell biology, genetics and molecular biology

• Microbial world and microbial life (1 class)
• Tools and techniques of microbiology (1 class)
• Humans and microbes in health and disease (2 classes)
• Host defense mechanisms in microbial infection (4 classes)
• Diagnosis of infectious disease (2 classes)
• Epidemiology and infection control (2 classes)
• Infectious diseases acquired through inhalation (5 classes)
• Infectious diseases acquired through ingestion (5 classes)
• Infectious diseases acquired through skin and mucosa or parenterally (5 classes)
• Exams (3 classes)

• Safety procedures and microscope use (1 session)
• Simple and Differential stains (1 session)
• Researching your paper topic (1 session)
• Classifying Bacteria by Enzymes and Staining (1 session)
• Antimicrobial Susceptibility Testing (1 session)
• Blood Cells and Blood Typing (1 session)

BI 273 - Human Anatomy and Physiology II

• Explain the concepts of homeostatis and positive and negative feedback
• Name, locate and describe the function of the major features of the central nervous system
• Name, locate and describe the function of the major features of the peripheral nervous system
• Describe the anatomy and physiology of the sense organs
• Describe the blood constituents and their properties
• Describe the anatomical features of the heart
• Explain cardiac function and regulation
• Describe the physical characteristics of blood vessels
• Name and locate major arteries and veins
• Describe the force regulating capillary exchange
• Describe the structure and function of the lymphatic system

• Cell biology, histology

• Homeostatis (1 class)
• Central nervous system (3 classes)
• Peripheral nervous system (3 classes)
• Sense organs (3 classes)
• Blood (2 classes)
• Heart (5 classes)
• Blood vessels and circulation (5 classes)
• Lymphatic and Immune Systems (4 classes)
• Exams (3 classes)

• Control of cardiovascular function (4 sessions)
• Heart rate and EKG (2 sessions)
• Sensation and reflexes (2 sessions)

BI 274 - Human Anatomy and Physiology III

• Explain the concepts of homeostasis and positive and negative feedback
• Name, locate and describe the function of the major features of the respiratory system
• Explain the function, control, and mechanics of respiration
• Describe how oxygen is carried and the factors affecting the oxygen carrying capacity
• Name, locate and describe the functions of the major features of the endocrine system
• Sketch the homeostatic feedback loops involving the major hormones
• Name, locate and describe the function of the major features of the urinary system
• Describe the process and regulation of urine formation
• Describe the feedback mechanisms used to maintain water balance
• Describe the control mechanisms for regulation of electrolytes and the importance of the regulation
• Describe the regulation of pH in terms of systems, mechanisms and time courses
• Name, locate and describe the function of the major structures of the GI system
• Name, locate and describe the major features of the male and female reproductive systems
• Graph the phases of the menstrual cycle over time
• Describe the time course of fetal development
• Describe the placental and fetal circulations

• Cell biology, histology

• Respiratory system (5 classes)
• Endocrine system (3 classes)
• Urinary system (5 classes)
• Water, electrolyte and acid-base balance (3 classes)
• Digestive system (3 classes)
• Male and female reproductive systems (5 classes)
• Development (2 classes)
• Exams (3 classes)

• Respiratory flow rates and volumes (2 sessions)
• Control of respiration (simulation) (1 session)
• Oxygen transport (simulation and BioPac (2 sessions)
• Control of respiration (1 session)
• Urinalysis (1 session)
• Fluid end electrolyte control (2 sessions)