PE 7022 - Clinical Extra-Corporeal Perfusion II

• An understanding of various priming solutions (e.g. their compositions and when to use them).
• An understanding of the concept of hemodilution and the ability to describe both positive and negative effects of such a technique.
• An understanding of the theory behind, as well as, the practical applications of myocardial protection.
• Knowledge of various solutions and methods utilized for cardioplegia.
• A knowledge and understanding of the various routes for administering cardioplegia and the pros and cons for each of them.
• A knowledge and understanding of the entire coagulation cascade, fibrinogen cascade, and complement system.
• An understanding of the role of platelets with regard to normal physiology, as well as, during CPB.
• A knowledge and understanding of the blood surface interface and how to minimize its’ detrimental effects.
• Knowledge of the pharmacology of anticoagulants and procoagulants.
• A knowledge and understanding of the concept of heparin resistance and the ability to diagnose heparin resistance versus an antithrombin III deficiency.
• Knowledge of what heparin induced thrombocytopenia (HIT) is and how to manage this type of patient during CPB.
• Knowledge of the process and possible deleterious effects of heparin neutralization with protamine sulfate (e.g. protamine reactions and treatment options).
• Knowledge of the effects of CPB on the following systems: pulmonary, renal, splanchnic, hepatic, viscera, and neurological.
• Knowledge of the endocrine, metabolic, and electrolyte response to CPB.
• A knowledge and understanding of the immune and inflammatory response to CPB. 

• None 

• No course topics appended.