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Mar 28, 2024
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PE 7022 - Clinical Extracorporeal Perfusion II3 lecture hours 0 lab hours 3 credits Course Description This course presents the Master of Science in Perfusion student with detailed descriptions of the pathophysiology of cardiopulmonary bypass. Topics include the following: priming solutions, hemodilution, myocardial protection (methods, solutions, and routes of administration), blood-surface interface, coagulation and anticoagulation management, and the effects of cardiopulmonary bypass on specific organ systems. (prereq: PE 7011 ) Course Learning Outcomes Upon successful completion of this course, the student will be able to:
- Identify the components of various priming solutions and explain the situations in which common priming solutions are used
- Explain the benefits and disadvantages of hemodilution during CPB
- Explain the theoretical underpinnings and practical applications of myocardial protection
- Describe the various solutions and arrest methods utilized for cardioplegia
- Describe the various delivery routes for cardioplegia administration and the benefits and drawbacks for each.
- Diagram the coagulation cascade and complement system
- Describe the role of platelets in normal physiology and how they are impacted during CPB
- Discuss challenges resulting from blood surface interface and ways to minimize its detrimental effects
- Exhibit knowledge of the pharmacology of anticoagulants and procoagulants
- Diagnose heparin resistance and differentiate it from antithrombin III deficiency
- Discuss the mechanism of heparin induced thrombocytopenia (HIT) and explain how to manage this type of patient during CPB
- Explain the process and possible deleterious effects of heparin neutralization via protamine sulfate (e.g. protamine reactions and treatment options)
- Discuss the impact of CPB on the following systems: pulmonary, renal, splanchnic, hepatic, viscera, and neurological
- Describe the endocrine, metabolic, and electrolyte responses to CPB
- Describe the immune and inflammatory responses associated with CPB
Prerequisites by Topic Coordinator Dr. Ronald Gerrits
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