Mar 28, 2024  
2019-2020 Graduate Academic Catalog 
    
2019-2020 Graduate Academic Catalog [ARCHIVED CATALOG]

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PE 7022 - Clinical Extracorporeal Perfusion II

3 lecture hours 0 lab hours 3 credits
Course Description
This course presents the Master of Science in Perfusion student with detailed descriptions of the pathophysiology of cardiopulmonary bypass. Topics include the following: priming solutions, hemodilution, myocardial protection (methods, solutions, and routes of administration), blood-surface interface, coagulation and anticoagulation management, and the effects of cardiopulmonary bypass on specific organ systems. (prereq: PE 7011 )
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
  • Identify the components of various priming solutions and explain the situations in which common priming solutions are used
  • Explain the benefits and disadvantages of hemodilution during CPB
  • Explain the theoretical underpinnings and practical applications of myocardial protection
  • Describe the various solutions and arrest methods utilized for cardioplegia
  • Describe the various delivery routes for cardioplegia administration and the benefits and drawbacks for each.
  • Diagram the coagulation cascade and complement system
  • Describe the role of platelets in normal physiology and how they are impacted during CPB
  • Discuss challenges resulting from blood surface interface and ways to minimize its detrimental effects
  • Exhibit knowledge of the pharmacology of anticoagulants and procoagulants
  • Diagnose heparin resistance and differentiate it from antithrombin III deficiency
  • Discuss the mechanism of heparin induced thrombocytopenia (HIT) and explain how to manage this type of patient during CPB
  • Explain the process and possible deleterious effects of heparin neutralization via protamine sulfate (e.g. protamine reactions and treatment options)
  • Discuss the impact of CPB on the following systems: pulmonary, renal, splanchnic, hepatic, viscera, and neurological
  • Describe the endocrine, metabolic, and electrolyte responses to CPB
  • Describe the immune and inflammatory responses associated with CPB

Prerequisites by Topic
  • None 

Coordinator
Dr. Ronald Gerrits



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