CH 2260 - Biochemistry for Life Sciences3 lecture hours 2 lab hours 4 credits
Course Description
This course introduces students to biomolecules, proteins, carbohydrates, lipids, and nucleic acids in relation to human physiology. Structure and function and their roles in the human body will be discussed. Structure and functions of hormones and neurotransmitters will be studied. Enzymes and their roles in metabolism will be discussed. Application of computers and online data bases such as Medline in the study of biomolecules will be introduced. (not open to engineering majors) (prereq: CH 2250 )
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
• identify alpha amino acids, write reactions of peptide bond formation, describe proteins in terms of size, function, fibrous, globular, structural hierarchy, explain hydrolysis and denaturation
• describe functions of carbohydrates, classify carbohydrates, describe stereoisomerism, write reactions of oxidation and glycoside formation, describe structure and use of polysaccharides
• classify lipids, draw structures of fats and oils, describe their chemical properties, describe phosphoglycerides, sphingolipids, describe major features of sphingolipids, identify steroids
• describe enzymes and how they work, factors affecting enzyme activity, explain enzyme inhibition, describe regulation of enzymes, recognize importance of enzymes in diseases
• identify nucleotides, describe structure of DNA, outline replication process, describe transcription and translation, explain how genetic code functions, describe mutations
• describe nutritional requirements, vitamins and minerals, outline stages of metabolism, role of ATP, coenzymes, describe metabolism of glucose in details, hormonal control of metabolism
• outline fat metabolism, describe medical conditions of ketonemia, ketonuria, ketosis, ketoacidosis
Prerequisites by Topic
• None
Course Topics
• amino acids, peptides, protein function, primary, secondary, tertiary, quaternary structures of proteins, protein hydrolysis and denaturation
• classes of carbohydrates, properties of mono, di and polysaccharides, stereochemistry of carbohydrates
• classification of lipids, structure chemical properties of fats and oils, phosphoglycerides, sphingolipids, trans fatty acids, LDL, HDL, cholesterol, biological membranes, steroids, bile salts, steroid hormones, prostaglandins
• enzyme nomenclature, enzyme co-factors, mechanism of enzyme action, factors affecting enzyme action, enzyme inhibition, enzyme regulation, medical applications of enzymes
• nucleic acids, structure of DNA and RNA, DNA replication, transcription, translation, genetic code, mutations
• nutritional requirements, macro and micronutrients, catabolism of food, ATP, coenzymes, blood glucose, glycolysis, citric acid cycle, oxidative phosphorylation, glycogen metabolism, hormonal regulation
• blood lipids, beta oxidation of fatty acids, ketone bodies and pathological conditions that cause their overproduction
Laboratory Topics
• Experiment #1: Properties of vitamins (439)
• Experiment #2: Chemistry of amino acids (pg 397)
• Experiment #3: Peptides and Proteins (pg.409)
• Experiment #4: Tests for carbohydrates-A, B, C, D (pg. 275)
• Experiment #5: Tests for carbohydrates- C, E and F (pg. 275) and diastase activity
• Experiment #6: Lipids (pg. 319)
• Experiment #7: Enzymes (pg. 423)
• Experiment #8: DNA components and extraction (pg. 309)
• Experiment #9: Analysis of Urine (pg. 477)
Coordinator
Vipin Paliwal
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