| |
Apr 25, 2024
|
|
|
|
|
BI 3100 - Stem Cell and Cancer Biology3 lecture hours 0 lab hours 3 credits
Course Description
This course covers a broad range of topics relevant to stem cell biology. This field brings together many aspects of basic and applied biology and medicine including development, regeneration/repair, and cancer. The course covers: pluripotency and reprogramming, pluripotent cell types, organ systems, stem cells and cancer, therapeutics and ethics. The lecture/discussion format gives students both a broad background and the opportunity to apply critical thinking skills to recent data in the field. The course also surveys the categories of tumors and their varying natures. Known mechanisms that lead to tumor cell development, multistep tumorigenesis, metastasis, tumor immunology, and cancer treatments will be examined in depth. (prereq: BI 102 or BI 1010 and junior standing)
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
- Understand pluripotency and cell reprogramming
- Understand the different cell types
- Understand organ systems
- Understand the relationship between stem cells and cancer
- Understand the different types of cancer therapeutics
- Understand the ethics behind stem cells
- Understand the ethics behind cancer
- Understand the different categories of tumors
- Understand tumor cell development
- Apply critical thinking skills in the stem cell field
- Apply critical thinking skills in the cancer biology field
Prerequisites by Topic
- General structure and chemical properties of atoms and molecules.
- Structure and functional properties of the macromolecules found in living matter
- Structural components of mammalian cells and explain their function
- Types of transport processes occurring across the cell membranes and the energy sources for them
- Mechanisms of intercellular communication
- Enzymes’ structural domains important for the chemical kinetics
- Mechanisms of energy storage, transfer, release, and use in cellular processes
- The processes of mitosis and meiosis and conditions under which they occur.
- Genetic terms and solving traditional genetic problems
- The processes of transcription and translation, including their regulation, and discuss their effect on the cell function.
- How changes in genetic material can occur.
- The major techniques involved in gene technology and describe specific uses of each technique.
- Designing and performing a scientific experiment, including hypothesis generation and testing
- Using statistical tests to interpret laboratory data.
- Standardized scientific report writing format
Course Topics
- Isolation and characteristics of human embryonic stem cells and future applications in tissue engineering therapies
- Epigenetics, stem cell pluripotency, and differentiation
- Stem cell pluripotency and differentiation
- Haematopoietic stem cells in therapy
- Isolation and Identification of neural stem/progenitor cells
- The role of epithelial-mesenchymal transition in cancer metastasis
- Regulation of breast cancer stem cells by mesenchymal stem cells in the metastatic niche
- Isolation and identification of neural cancer stem/progenitor cells
- Colon stem cells in colorectal cancer
- Prostate cancer and prostate cancer stem cells
- Stem cells and pancreatic cancer
- NANOG in cancer development
- Liver cancer stem cells and hepatocarcinogenesis
- Cancer stem cell biomarkers
- Interactomic analysis of stem cell marker NANOG in prostate cancer setting
Coordinator
Dr. Eryn Hassemer
Add to Portfolio (opens a new window)
|
|
Skip to Main Content
