Apr 18, 2024  
2019-2020 Graduate Academic Catalog 
    
2019-2020 Graduate Academic Catalog [ARCHIVED CATALOG]

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PE 647 - The Design of Experiments

3 lecture hours 0 lab hours 3 credits
Course Description
In addition to covering the appropriate use of both parametric and nonparametric statistics, this graduate course also addresses the broader issue of experimental design and methodology as it applies to medical research. Emphasis is given to the entire research process from defining and refining the original research question(s) to selection of the appropriate statistical design, interpretation and presentation of results. The use of statistical software is also used throughout the course. (prereq: graduate standing or consent of instructor)
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
  • Calculate standard deviation, range, coefficient of variation, percentiles, and the assessment of normality within data sets
  • Identify measurement scales (ratio, interval, ordinal, nominal) and their significance in statistical designs
  • Identify and distinguish between independent and dependent variables within research studies
  • Explain the concepts, calculations, and use associated with measures of sensitivity, specificity, positive and negative predictive values as they relate to diagnostic screening tests
  • Formulate statistically testable hypotheses in both mathematical and English terms
  • Explain the potential causes of Type I and Type II error and the interdependent influences of alpha, sample size, and effect size on statistical power
  • Appropriately use the three variations of the t-test and how to test for compliance with their underlying assumptions
  • Appropriately use fixed and repeated-measures ANOVA within research designs and test for their underlying assumptions
  • Explain the structure, value, and interpretation of the ANOVA source table.
  • Explain when and why multiple comparison tests are needed when performing an ANOVA
  • Explain the advantages and disadvantages associated with repeated-measures designs
  • Explain the concepts and use of correlation, single, multiple, polynomial, and logistic regression models - including knowing how to assess the fit and quality of these models
  • Explain the value and use of basic nonparametric statistical tests
  • Statistically, graphically, and completely evaluate and interpret raw experimental data sets
  • Critically evaluate and properly assess the statistical designs and their underlying assumptions used within research studies

Prerequisites by Topic
  • None 

Course Topics
  • Research concepts, descriptive statistics, hypothesis testing, diagnostic tests (2 class periods)
  • Use and interpretation of the single-sample, paired, and unpaired t-test (1 class period)
  • Use and interpretation of the fixed-effect and repeated-measures ANOVA; journal article critique (2 class periods)
  • Correlation and regression analysis (3 class periods)
  • Nonparametric statistical tests (chi-square, Mann-Whitney U, Kruskal-Wallis) (1 class period)

Coordinator
Dr. Ronald Gerrits



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