Aug 19, 2019  
2017-2018 Undergraduate Academic Catalog 
2017-2018 Undergraduate Academic Catalog [ARCHIVED CATALOG]

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EB 3570 - Kinetics and Bioreactor Design

4 lecture hours 0 lab hours 4 credits
Course Description
This course addresses the selection of the optimal configuration and size of production scale bioreactors for specific applications. The design of fermentation reactors and cell culture type bioreactors and their applications will be discussed. Course topics include: reactor types, reaction kinetics (batch reactor, semi-continuous reactor, continuous reactors (CSTR, PFR, PBR), Chemostats), and fundamental reaction parameters, substrate consumption kinetics, production kinetics for bioreactions, mass and energy balances on the reactors. Course material is applied to practical reactor selection, sizing, scale-up and operation. (prereq: BI 102 , CH 223 , EB 3510 , EB 3620 )
Course Learning Outcomes
Upon successful completion of this course, the student will be able to:
  • Derive and apply macroscopic mole and energy balances to size reactors
  • Analyze lab data to ascertain the kinetics of a reaction and scale-up design of a bioreactor from lab data
  • Distinguish between various types and arrangements of reactors and understand their operation
  • Design or select a bioreactor for a specific purpose
  • Use a mathematical tool to solve systems of equations

Prerequisites by Topic
  • Chemical and Biochemical reaction kinetics, collection of reaction rate data, MATLAB programming, mass and energy balances

Course Topics
  • Mole balances and introduction to Polymath
  • Design equations, Rate vs. Conversion plots
  • Types of reactors, Reactor arrangement/staging, Rate laws and Stoichiometry
  • Isothermal reactor design-irreversible and reversible reactions
  • Pressure drop, Membrane reactors
  • Batch, Semi-batch, CTSR, recycle and aerated reactors
  • Analysis of rate data, multiple reactions, heat effects/energy balance
  • Enzymes, MM kinetics, enzyme inhibition, Fermenters
  • Bioreactors, cell growth kinetics/rate laws, scale up and operation
  • Review of reactor design, selection, impeller selection as a function of cell type
  • Problem solving using Polymath

Serdar Ozturk

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