BME 3610 - Biomaterials

3 lecture hours 0 lab hours 3 credits

Course Description
This course presents principles related to the selection and use of biomaterials. The course begins with topics in mechanics of materials and material science that are salient to biomaterials properties and applications. In addition to mechanical properties, other properties such as corrosivity and imaging characteristics are discussed. General characteristics and biomedical applications of metals, ceramics, polymers, and composite materials are covered. The course includes exploration of the biological tissue responses to implanted materials. Finally, practical issues of incorporating biomaterials in medical devices are discussed, including testing methods, relevant medical device standards, and regulatory considerations.
Prereq: BIO 1110, CHM 1010, MEC 2010 (quarter system prereq: BI 102, CH 200, ME 205)
Note: None
This course meets the following Raider Core CLO Requirement: None

Course Learning Outcomes
Upon successful completion of this course, the student will be able to:

Explain the different ways that loads can be applied to materials
Perform calculations involving elastic loading of materials, including stress/strain relationships and bending
Describe modes of failure for solid materials
Apply models to describe mechanical behaviors of viscoelastic materials
Identify the types of chemical bonds associated with solids, ceramics and polymer materials
Explain typical crystal structures of solids and how defects affect mechanical properties
Use phase diagrams to identify phases present and associated microstructures of materials, as well as to explain processing techniques involving phase transformations
Explain how corrosion, fatigue and wear can affect the performance of materials in a physiological environment
Define biocompatibility and describe the biological interactions and responses that occur at the surface of implanted materials and the effect of these responses on the human body
Describe the typical advantages and disadvantages of metals, polymers and ceramics as biomaterials
Solve biomedical engineering problems related to selection and processing of metallic, ceramic, and polymeric biomaterials
Identify typical materials used for biomedical devices such as sutures, artificial heart valves, oxygenator membranes, and other devices that involve blood contact, contact lenses, orthopedic implants, and dental implants
Identify applications for bioactive and bioresorbable materials, and explain how specific biomaterials achieve these properties
Explain structures of composite materials and how advantages can be achieved in composite biomaterials
Explain how biomaterials are tested, how medical device standards apply, and how they are regulated

Prerequisites by Topic

Chemical bond types and characteristics
Mammalian cell biology
Structure and properties of biological macromolecules and water
Static analysis of forces and moments

Course Topics

Types of stress and modes of loading
Axial, multiaxial and shear loading analysis
Pure bending analysis
Models of viscoelastic behavior
Chemical bond types in biomaterials
Crystal structures and defects
Phase diagram interpretation and analysis for biomaterials
Wear, fatigue and corrosion of biomaterials
Biocompatibility definition and host responses to biomaterials
Tissue-biomaterial interactions
Electrical, imaging and other non-mechanical properties of biomaterials
Metals as biomaterials: processing techniques, orthopedic metals, and specialty metals
Ceramics as biomaterials: structure and fracture mechanics, bioinert ceramics, bioactive and bioresorbable ceramics
Polymers as biomaterials: polymerization process, structure-property relationships, processing of polymers, bioinert and bioresorbable polymers, and their applications
Composites as biomaterials: general characteristics, structure-property relationships, applications
Testing of biomaterials and relevant medical device standards and regulatory considerations

Coordinator
Dr. Jeff LaMack

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