CHM 2310 - Biochemistry

3 lecture hours 2 lab hours 4 credits

Course Description
This course is designed to train and educate students with essential and central concepts, principles, and applications of biochemistry. Foundational knowledge of biochemistry is essential in disciplines like medicine, nutrition, pharmacology, biotechnology, genomics, bioremediation, agriculture, bioinformatics, and in several engineering fields. The three-dimensional structures of biomolecules are explored in the context of their multi-functions and their microenvironments within living organisms' metabolic pathways are introduced. The course enhances the ability of students to address changes, needs, and demands of their own major fields as well. The lab activity allows hands-on experience on concepts taught in lecture.
Prereq: CHM 1020 (quarter system prereq: CH 201 or CH 222)
Note: None
This course meets the following Raider Core CLO Requirement: None

Course Learning Outcomes
Upon successful completion of this course, the student will be able to:

Recognize and identify organic functional groups used in biochemistry
Identify and name different types of biomolecules including DNA, RNA, proteins, lipids, and carbohydrates
Describe the structures and functions of the biomolecules, DNA, RNA, proteins, lipids, and establish the structure-function relationship for the different biomolecules
Manipulate basic structural and functional concepts about biomolecules and biopolymers like nucleic acids, carbohydrates, proteins, enzymes, and lipids
Translate the genetic code and understand the importance of single, double or multiple mutations at genomic, transcriptional, or translational levels
Analyze and apply the interrelationship of metabolism reactions with those of the human body and metabolic processes essential to body's normal functions
Identify and apply biochemistry concepts to biotechnology, bioinformatics, cell culture, synthetic biology, and other related fields
Participate in scientific conversations about biochemistry using correct terminology, ask relevant questions in a seminar or colloquium with confidence, and take part in science activities (presentations and meetings) individually or as a team member
Use proper and accurate basic biochemistry laboratory techniques and handle the biochemicals appropriately under a variety of circumstances
Handle and dispose all biochemical materials safely
Identify and practice BSL-1 lab rules and ethics

Prerequisites by Topic

Covalent, ionic, H-bonding, and Van der Waal's interactions
Positive and negative ions
Functional groups including alcohols, amines and amides, carboxylic acids and acid derivatives, thiols, aromatic vs aliphatic, aldehydes and ketones, alkanes, alkenes, alkynes
Nucleophiles and electrophiles

Course Topics

Past, present, and future of biochemistry
Introduction to basic organic functional groups
Amino acids, peptides, and proteins: functions and applications
Amino acids, peptides and proteins: structures and properties
Specific proteins: structures and functions
pH, pKa, PI
Enzymes: structures and applications
Medical and industrial applications
MM equation
Inhibitors and applications
DNA and RNA: structure and function
DNA and RNA: replication and transcription/polymerases
Genetic code
Translation
Carbohydrates: structures and functions
Lipids: structures and functions
Metabolism, glycolysis, TCA cycle, oxidative phosphorylation, ATP production
ETC and photosynthesis
Biochem applications: bioinformatics, biotechnology, genomics, cell culture, synthetic biology, microbiology and vaccinology, metabolic engineering, biomolecular engineering

Laboratory Topics

Introduction to biomolecules
Properties of amino acids and peptide bonds
Understanding the 3D structure of proteins
Introduction to the properties of proteins
Enzyme catalyzed reactions
Enzyme kinetics and inhibitors
Modeling the nucleic acids: parts 1,2,3
Modeling the nucleic acids: parts 4,5,6
Introduction to the properties pf carbs
Introduction to the properties of lipids
Modeling aerobic cellular respiration
Modeling the process of photosynthesis
Photosynthesis-electron-proton
Translocation in isolated thylakoids

Coordinator
Dr. Vipin Paliwal

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